{"id":517,"date":"2020-03-10T18:30:00","date_gmt":"2020-03-10T15:30:00","guid":{"rendered":"https:\/\/www.sightsciences.com\/ous\/?p=517"},"modified":"2020-03-10T18:30:00","modified_gmt":"2020-03-10T15:30:00","slug":"sight-sciences-announces-publication-of-first-ever-multicenter-migs-study-in-childhood-glaucoma","status":"publish","type":"post","link":"https:\/\/www.sightsciences.com\/ous\/sight-sciences-announces-publication-of-first-ever-multicenter-migs-study-in-childhood-glaucoma\/","title":{"rendered":"Sight Sciences Announces Publication of First-Ever Multicenter MIGS study in Childhood Glaucoma"},"content":{"rendered":"
\n

Sight Sciences, Inc., a growth-stage medical device company transforming the two fastest-growing segments in ophthalmology and optometry, glaucoma and dry eye disease, today announced that positive outcomes from a new multicenter study of one of the OMNI\u00ae<\/sup>\u00a0Surgical System\u2019s predecessor devices, TRAB\u00ae<\/sup>360, were published in the American Journal of Ophthalmology.<\/p>\n

 <\/p>\n

Following a 2019 publication1<\/sup>\u00a0of a clinical study which evaluated the safety and effectiveness of circumferential ab interno trabeculotomy (goniotomy) using TRAB360 in standalone MIGS surgery in adults, this study is the first multicenter trial to evaluate the same procedure performed in pediatric patients. The study, titled \u201cTrabeculotomy Ab Interno with the TRAB360 Device for Childhood Glaucomas,\u201d2<\/sup>\u00a0is a multicenter, retrospective interventional case series of 46 eyes in 41 patients with a median age of 12 months and a median follow-up period of 14.5 months. Median pre-operative IOP was 30 mm Hg and median post-operative IOP was 18 mm Hg from this standalone pediatric surgery at the median follow-up period of 14.5 months.<\/p>\n

 <\/p>\n

Surgical success, defined as postoperative intraocular pressure (IOP) of \u226424 mm Hg with or without medications and no additional surgery required to control IOP, was achieved in 67.4% of eyes. Among 40 eyes for which trabeculotomy with the TRAB360 was the first glaucoma surgery, the success rate was 70%. Among 18 primary congenital glaucoma (PCG) eyes for which trabeculotomy with the TRAB360 was the first glaucoma surgery, the success rate was 83.3%. Cyclodialysis-related hypotony was reported in two eyes (4.3%). Both of these eyes had angle anomalies that likely predisposed them to forming cyclodialysis clefts when traction was exerted on the trabecular meshwork. One eye resolved without further intervention and the other eye required surgical intervention to treat the hypotony. No other significant complications were reported.<\/p>\n

 <\/p>\n

\u201cFor years, my pediatric glaucoma specialist colleagues around the country and I have been using the Sight Sciences devices in pediatric cases because the technology uniquely provides access to all 360 degrees of the diseased conventional outflow pathway through a single clear corneal incision.”<\/p><\/blockquote>\n

 <\/p>\n

\u201cThis study, the first to critically evaluate outcomes of circumferential ab interno trabeculotomy using the TRAB360 device to treat childhood glaucoma, shows that the procedure is a compelling early surgical intervention in pediatric glaucoma,\u201d said Dr. Alana Grajewski, Professor of Clinical Ophthalmology and Director of The Samuel & Ethel Balkan International Pediatric Glaucoma Center at the Bascom Palmer Eye Institute, and co-author of the study. \u201cFor years, my pediatric glaucoma specialist colleagues around the country and I have been using the Sight Sciences devices in pediatric cases because the technology uniquely provides access to all 360 degrees of the diseased conventional outflow pathway through a single clear corneal incision. Moving beyond TRAB360 with OMNI, we are adding viscodilation of the distal outflow system to the trabeculotomy, thereby providing our patients two sequential, comprehensive, canal-based MIGS procedures that together can target all 360 degrees of disease at all three levels of outflow resistance.\u201d<\/p>\n

 <\/p>\n

OMNI targets all three levels of outflow resistance: a trabeculotomy procedure to address trabecular meshwork, and a viscodilation procedure to address Schlemm\u2019s canal and the collector channels.<\/p>\n

 <\/p>\n

\u201cAs an early adopter of Sight Sciences\u2019 first two single-purpose devices\u2014TRAB360 for trabeculotomy and VISCO360 for canal viscodilation\u2014I am pleased to have provided positive reinforcement and encouragement to the Sight Sciences team early on as they pushed forward to develop the fully integrated, dual-procedure OMNI Surgical System so that glaucoma surgeons around the world could better care for their patients with a comprehensive, multi-modal canal-based solution,\u201d continued Dr. Grajewski.<\/p>\n

 <\/p>\n

\u201cReviewing the positive clinical outcomes of the OMNI predecessor procedure in childhood glaucoma and thinking about our company\u2019s role in helping equip pediatric surgeons with the tools they need to fight pediatric blindness has been truly inspirational for our team here at Sight Sciences, and is arguably one of the most satisfying and rewarding developments in my career personally,\u201d said Sight Sciences co-founder and CEO Paul Badawi. \u201cWe have really enjoyed our close relationships with the pediatric glaucoma community and have learned so much from them over the years. As canal physiology experts, pediatric ophthalmic surgeons such as Dr. Alana Grajewski (Bascom Palmer), Dr. James Brandt (UC Davis), and many other surgeons beyond this published study have been major sources of inspiration to us over the years as we listen to customer needs and strive to provide them with the best shots on goal within the conventional outflow pathway.\u201d<\/p>\n

 <\/p>\n

About OMNI\u00ae<\/sup>\u00a0Surgical System<\/h4>\n

 <\/p>\n

The OMNI\u00ae<\/sup>\u00a0Surgical System is a manually operated device for delivery of small amounts of viscoelastic fluid, for example Healon\u00ae<\/sup>\u00a0or HealonGV\u00ae<\/sup>\u00a0from Abbott Medical Optics (AMO), Amvisc\u00ae<\/sup>\u00a0from Bausch & Lomb, or PROVISC\u00ae<\/sup>\u00a0from Alcon, during ophthalmic surgery. It is also indicated to cut trabecular meshwork tissue during trabeculotomy procedures.<\/p>\n

 <\/p>\n

The OMNI\u00ae<\/sup>\u00a0Surgical System is a next-generation technology that combines the distinct functions of its two predecessor devices \u2013 TRAB\u00ae<\/sup>360 for trabeculotomy and VISCO360\u00ae<\/sup>\u00a0for transluminal viscoelastic delivery \u2013 into one device so that all three sources of resistance in the conventional outflow pathway (trabecular meshwork, Schlemm\u2019s canal, and collector channels) can be targeted with a single device and single surgery.<\/p>\n

 <\/p>\n

The OMNI\u00ae<\/sup>\u00a0System should not be used in cases where there is insufficient visualization of the anterior chamber. The following conditions may prohibit sufficient visualization required for safe and successful cannula and microcatheter placement: corneal edema, corneal haze, corneal opacity, or any other conditions that may inhibit surgeon view.<\/p>\n

 <\/p>\n

About TRAB\u00ae<\/sup>360<\/h4>\n

 <\/p>\n

The TRAB\u00ae<\/sup>360 Trabeculotomy System is a trabeculotome, a manual surgical ophthalmic instrument used to mechanically cut trabecular meshwork.<\/p>\n

 <\/p>\n

The OMNI\u00ae<\/sup>\u00a0Surgical System and TRAB\u00ae<\/sup>360 Trabeculotomy System are tools, not treatments, and are indicated for use as specified above; they are not specifically cleared by the FDA to lower intraocular pressure in patients with open angle glaucoma.<\/p>\n

 <\/p>\n

About Sight Sciences<\/h4>\n

 <\/p>\n

Founded in 2011, Sight Sciences has developed, and is now commercial with intelligently designed and engineered products that target the underlying causes of the world\u2019s most prevalent eye diseases. The company\u2019s surgical glaucoma product portfolio features the OMNI\u00ae<\/sup>\u00a0Surgical System, a dually-indicated device that facilitates the performance of both trabeculotomy and transluminal viscoelastic delivery. Using proprietary multi-modal functionality, OMNI allows surgeons to target all three sources of resistance in the conventional outflow pathway (trabecular meshwork, Schlemm\u2019s canal, and collector channels) with a single device and single corneal incision.<\/p>\n

 <\/p>\n

The company\u2019s non-surgical Dry Eye product portfolio consists of TearCare\u00ae<\/sup>\u00a0for ophthalmologists and optometrists. TearCare is a software-controlled, wearable eyelid technology that delivers highly targeted and adjustable heat to the meibomian glands of the eyelids. Leveraging the full functionality of the blinking eye, proprietary SmartLid\u00ae<\/sup>\u00a0technology is designed to facilitate natural meibum expression when meibum is in its softened phase. TearCare\u2019s innovative, \u201cequipment-light\u201d product design and the intuitive procedure facilitates create a highly attractive clinical and economic model for eye care providers.<\/p>\n

 <\/p>\n

For more information, please visit sightsciences.com.<\/p>\n

 <\/p>\n

TearCare\u00ae<\/sup>\u00a0and OMNI\u00ae<\/sup>\u00a0are registered trademarks of Sight Sciences.
\n\u00a9 2020 Sight Sciences. All rights reserved.<\/p>\n

 <\/p>\n

1<\/sup>\u00a0Sarkisian S, Mathews B, Ding K, Patel A, Nicek Z. 360\u00b0 ab-interno trabeculotomy in refractory primary open-angle glaucoma. Clin Ophthalmol. 2019; 13: 161\u2013168. doi: 10.2147\/OPTH.S189260. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6333157\/
\n2<\/sup>\u00a0Areaux R, et al, \u201cTrabeculotomy Ab Interno With the Trab360 Device for Childhood Glaucomas,\u201d American Journal of Ophthalmology 2020;209:178\u2013186, https:\/\/doi.org\/10.1016\/j.ajo.2019.10.014.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Sight Sciences, Inc., a growth-stage medical device company transforming the two fastest-growing segments in ophthalmology and optometry, glaucoma and dry eye disease, today announced that positive outcomes from a new multicenter study of one of the OMNI\u00ae\u00a0Surgical System\u2019s predecessor devices, TRAB\u00ae360, were published in the American Journal of Ophthalmology.   Following a 2019 publication1\u00a0of a […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[6,5],"tags":[],"class_list":["post-517","post","type-post","status-publish","format-standard","hentry","category-news","category-omni"],"acf":[],"yoast_head":"\nSight Sciences Announces Publication of First-Ever Multicenter MIGS study in Childhood Glaucoma - International<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sightsciences.com\/ous\/sight-sciences-announces-publication-of-first-ever-multicenter-migs-study-in-childhood-glaucoma\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sight Sciences Announces Publication of First-Ever Multicenter MIGS study in Childhood Glaucoma\" \/>\n<meta property=\"og:description\" content=\"Sight Sciences, Inc., a growth-stage medical device company transforming the two fastest-growing segments in ophthalmology and optometry, glaucoma and dry eye disease, today announced that positive outcomes from a new multicenter study of one of the OMNI\u00ae\u00a0Surgical System\u2019s predecessor devices, TRAB\u00ae360, were published in the American Journal of Ophthalmology.   Following a 2019 publication1\u00a0of a […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sightsciences.com\/ous\/sight-sciences-announces-publication-of-first-ever-multicenter-migs-study-in-childhood-glaucoma\/\" \/>\n<meta property=\"og:site_name\" content=\"International\" \/>\n<meta property=\"article:published_time\" content=\"2020-03-10T15:30:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.sightsciences.com\/ous\/wp-content\/uploads\/sites\/3\/2024\/04\/SISC_RTS_Logo_Primary_RGB_P1-1200.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"admin-dev\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin-dev\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.sightsciences.com\/ous\/sight-sciences-announces-publication-of-first-ever-multicenter-migs-study-in-childhood-glaucoma\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.sightsciences.com\/ous\/sight-sciences-announces-publication-of-first-ever-multicenter-migs-study-in-childhood-glaucoma\/\"},\"author\":{\"name\":\"admin-dev\",\"@id\":\"https:\/\/www.sightsciences.com\/ous\/#\/schema\/person\/88f84507b2364aa1168168756f61f091\"},\"headline\":\"Sight Sciences Announces Publication of First-Ever Multicenter MIGS study in Childhood Glaucoma\",\"datePublished\":\"2020-03-10T15:30:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.sightsciences.com\/ous\/sight-sciences-announces-publication-of-first-ever-multicenter-migs-study-in-childhood-glaucoma\/\"},\"wordCount\":1223,\"commentCount\":0,\"articleSection\":[\"News\",\"OMNI\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.sightsciences.com\/ous\/sight-sciences-announces-publication-of-first-ever-multicenter-migs-study-in-childhood-glaucoma\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.sightsciences.com\/ous\/sight-sciences-announces-publication-of-first-ever-multicenter-migs-study-in-childhood-glaucoma\/\",\"url\":\"https:\/\/www.sightsciences.com\/ous\/sight-sciences-announces-publication-of-first-ever-multicenter-migs-study-in-childhood-glaucoma\/\",\"name\":\"Sight Sciences Announces Publication of First-Ever Multicenter MIGS study in Childhood Glaucoma - 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